Mission-critical and even safety-critical applications have crept into the Internet of Things (IoT). In these applications, failure might lead to injury and even loss of life. This talk will present the architectural challenges that come with deploying mission-critical IoT systems in hazardous industries. Attendees will learn about hazardous industries, some of their challenges, and how the IoT can help. We will dive into new challenges that have emerged in the IoT, the need for trustworthy software, impacts on software architecture, and finally how to mitigate the threats from common mode failures, human error, and even malware. These things must be addressed before we have problems, not as a post-mortem of a capsized system.